Kim De Keersmaecker Selected Research

Eltanexor

1/2021	PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia.
11/2020	The XPO1 Inhibitor KPT-8602 Synergizes with Dexamethasone in Acute Lymphoblastic Leukemia.

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Kim De Keersmaecker Research Topics

Disease

20	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 04/2022 - 06/2005
19	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma (T-ALL) 01/2023 - 06/2005
16	Neoplasms (Cancer) 12/2023 - 04/2008
13	Leukemia 04/2024 - 06/2011
2	T-Cell Leukemia (Leukemia, T Cell) 04/2024 - 11/2010
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 02/2024 - 12/2023
2	Breast Neoplasms (Breast Cancer) 01/2021 - 02/2017
2	Carcinogenesis 01/2021 - 02/2015
2	Multiple Myeloma 01/2020 - 01/2017
2	Genetic Translocation (Chromosomal Translocation) 10/2011 - 07/2008
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 06/2011 - 06/2005
1	Prostatic Neoplasms (Prostate Cancer) 01/2023
1	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2023
1	Lung Neoplasms (Lung Cancer) 01/2023
1	Diamond-Blackfan Anemia (Anemia, Diamond Blackfan) 01/2022
1	Congenital Bone Marrow Failure Syndromes 01/2022
1	Reticulocytosis 01/2020
1	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 01/2019
1	Splenomegaly 01/2019
1	Lymphoma (Lymphomas) 01/2019
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2019

Drug/Important Bio-Agent (IBA)

9	Ribosomal Proteins (Ribosomal Protein)IBA 01/2022 - 02/2015
7	Glycine (Aminoacetic Acid)FDA LinkGeneric 02/2024 - 11/2019
7	Serine (L-Serine)FDA Link 02/2024 - 11/2019
7	Transcription Factors (Transcription Factor)IBA 01/2023 - 08/2010
5	Proteins (Proteins, Gene)FDA Link 01/2022 - 02/2013
5	Imatinib Mesylate (Gleevec)FDA Link 01/2021 - 06/2005
4	Phosphotransferases (Kinase)IBA 11/2021 - 06/2005
3	Sertraline (Zoloft)FDA LinkGeneric 12/2023 - 01/2021
3	Dexamethasone (Maxidex)FDA LinkGeneric 11/2020 - 04/2008
2	Homeodomain Proteins (Proteins, Homeobox)IBA 04/2024 - 11/2010
2	CytokinesIBA 12/2023 - 06/2010
2	DNA (Deoxyribonucleic Acid)IBA 04/2022 - 11/2021
2	Amyloid Precursor Protein Secretases (beta-Secretase)IBA 01/2021 - 04/2008
2	EltanexorIBA 01/2021 - 11/2020
2	Gamma Secretase Inhibitors and ModulatorsIBA 01/2021 - 04/2008
2	ruxolitinibIBA 01/2021 - 12/2019
2	Vincristine (Oncovin)FDA LinkGeneric 11/2020 - 04/2008
2	RNA (Ribonucleic Acid)IBA 11/2019 - 01/2013
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2014 - 07/2008
1	Etoposide (VP 16)FDA LinkGeneric 01/2023
1	NucleotidesIBA 04/2022
1	Antidepressive Agents (Antidepressants)IBA 01/2021
1	Thimerosal (Thiomersal)IBA 01/2021
1	MRK 560IBA 01/2021
1	Transfer RNA (tRNA)IBA 01/2021
1	deoxyguanosine triphosphate (dGTP)IBA 12/2020
1	forodesineIBA 12/2020
1	Doxorubicin (Adriamycin)FDA LinkGeneric 11/2020
1	carfilzomibIBA 01/2020
1	Ribosomal DNA (rDNA)IBA 01/2020
1	Messenger RNA (mRNA)IBA 11/2019
1	Adenosine Triphosphate (ATP)IBA 01/2019
1	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019
1	venetoclaxIBA 01/2019
1	Complement Factor B (Factor B)IBA 01/2019
1	DNA-Directed RNA Polymerases (RNA Polymerase)IBA 10/2017
1	bosutinibIBA 01/2014
1	Lymphocyte Specific Protein Tyrosine Kinase p56(lck) (p56 lck)IBA 01/2014
1	src-Family KinasesIBA 01/2014
1	Dasatinib (BMS 354825)FDA Link 01/2014
1	Phosphoric Monoester Hydrolases (Phosphatases)IBA 05/2012
1	tyrosine receptor (receptor, tyrosine)IBA 05/2012
1	Protein Isoforms (Isoforms)IBA 04/2012
1	PTEN Phosphohydrolase (PTEN Phosphatase)IBA 04/2012
1	Phosphatidylinositols (Phosphatidylinositol)IBA 04/2012
1	Polycomb Repressive Complex 2IBA 02/2012
1	RNA-Binding Proteins (RNA-Binding Protein)IBA 08/2010
1	T-Cell Antigen Receptors (T-Cell Receptor)IBA 08/2010
1	Protein Tyrosine PhosphatasesIBA 06/2010
1	Nuclear Pore Complex Proteins (Nucleoporins)IBA 07/2008
1	GlucocorticoidsIBA 04/2008
1	Therapeutic UsesIBA 04/2008

Therapy/Procedure

7	Therapeutics 10/2018 - 06/2011
4	Drug Therapy (Chemotherapy) 01/2023 - 04/2008
2	Radiotherapy 02/2024 - 12/2023
1	Immunomodulation 12/2023
1	Precision Medicine 12/2020